Populus balsamifera Extract and Its Active Component Salicortin Reduce Obesity and Attenuate Insulin Resistance in a Diet-Induced Obese Mouse Model.
Identifieur interne : 002537 ( Main/Exploration ); précédent : 002536; suivant : 002538Populus balsamifera Extract and Its Active Component Salicortin Reduce Obesity and Attenuate Insulin Resistance in a Diet-Induced Obese Mouse Model.
Auteurs : Despina Harbilas [Canada] ; Diane Vallerand ; Antoine Brault ; Ammar Saleem ; John T. Arnason ; Lina Musallam ; Pierre S. HaddadSource :
- Evidence-based complementary and alternative medicine : eCAM [ 1741-427X ] ; 2013.
Abstract
Populus balsamifera L. (BP) is a medicinal plant stemming from the traditional pharmacopoeia of the Cree of Eeyou Istchee (CEI-Northern Quebec). In vitro screening studies revealed that it strongly inhibited adipogenesis in 3T3-L1 adipocytes, suggesting potential antiobesity activity. Salicortin was identified, through bioassay-guided fractionation, as the active component responsible for BP's activity. The present study aimed to assess the potential of BP and salicortin at reducing obesity and features of the metabolic syndrome, in diet-induced obese C57Bl/6 mice. Mice were subjected to high fat diet (HFD) for sixteen weeks, with BP (125 or 250 mg/kg) or salicortin (12.5 mg/kg) introduced in the HFD for the last eight of the sixteen weeks. BP and salicortin effectively reduced whole body and retroperitoneal fat pad weights, as well as hepatic triglyceride accumulation. Glycemia, insulinemia, leptin, and adiponectin levels were also improved. This was accompanied by a small yet significant reduction in food intake in animals treated with BP. BP and salicortin (slightly) also modulated key components in signaling pathways involved with glucose regulation and lipid oxidation in the liver, muscle, and adipose tissue. These results confirm the validity of the CEI pharmacopoeia as alternative and complementary antiobesity and antidiabetic therapies.
DOI: 10.1155/2013/172537
PubMed: 23781256
PubMed Central: PMC3678421
Affiliations:
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Box 6128, Downtown Station, Montréal, QC, Canada H3C 3J7 ; Institute of Nutrition and Functional Foods, Université Laval, Quebec City, QC, Canada G1V 0A6 ; Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada H1W 4A4.</nlm:affiliation><country>Canada</country><wicri:regionArea>Canadian Institutes of Health Research (CIHR) Team in Aboriginal Antidiabetic Medicines, Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, QC, Canada H3C 3J7 ; Natural Health Products and Metabolic Diseases Laboratory, Department of Pharmacology, Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, QC, Canada H3C 3J7 ; Institute of Nutrition and Functional Foods, Université Laval, Quebec City, QC, Canada G1V 0A6 ; Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Vallerand, Diane" sort="Vallerand, Diane" uniqKey="Vallerand D" first="Diane" last="Vallerand">Diane Vallerand</name></author><author><name sortKey="Brault, Antoine" sort="Brault, Antoine" uniqKey="Brault A" first="Antoine" last="Brault">Antoine Brault</name></author><author><name sortKey="Saleem, Ammar" sort="Saleem, Ammar" uniqKey="Saleem A" first="Ammar" last="Saleem">Ammar Saleem</name></author><author><name sortKey="Arnason, John T" sort="Arnason, John T" uniqKey="Arnason J" first="John T" last="Arnason">John T. Arnason</name></author><author><name sortKey="Musallam, Lina" sort="Musallam, Lina" uniqKey="Musallam L" first="Lina" last="Musallam">Lina Musallam</name></author><author><name sortKey="Haddad, Pierre S" sort="Haddad, Pierre S" uniqKey="Haddad P" first="Pierre S" last="Haddad">Pierre S. Haddad</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23781256</idno><idno type="pmid">23781256</idno><idno type="doi">10.1155/2013/172537</idno><idno type="pmc">PMC3678421</idno><idno type="wicri:Area/Main/Corpus">002559</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002559</idno><idno type="wicri:Area/Main/Curation">002559</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">002559</idno><idno type="wicri:Area/Main/Exploration">002559</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Populus balsamifera Extract and Its Active Component Salicortin Reduce Obesity and Attenuate Insulin Resistance in a Diet-Induced Obese Mouse Model.</title><author><name sortKey="Harbilas, Despina" sort="Harbilas, Despina" uniqKey="Harbilas D" first="Despina" last="Harbilas">Despina Harbilas</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Institutes of Health Research (CIHR) Team in Aboriginal Antidiabetic Medicines, Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, QC, Canada H3C 3J7 ; Natural Health Products and Metabolic Diseases Laboratory, Department of Pharmacology, Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, QC, Canada H3C 3J7 ; Institute of Nutrition and Functional Foods, Université Laval, Quebec City, QC, Canada G1V 0A6 ; Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada H1W 4A4.</nlm:affiliation><country>Canada</country><wicri:regionArea>Canadian Institutes of Health Research (CIHR) Team in Aboriginal Antidiabetic Medicines, Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, QC, Canada H3C 3J7 ; Natural Health Products and Metabolic Diseases Laboratory, Department of Pharmacology, Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, QC, Canada H3C 3J7 ; Institute of Nutrition and Functional Foods, Université Laval, Quebec City, QC, Canada G1V 0A6 ; Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Vallerand, Diane" sort="Vallerand, Diane" uniqKey="Vallerand D" first="Diane" last="Vallerand">Diane Vallerand</name></author><author><name sortKey="Brault, Antoine" sort="Brault, Antoine" uniqKey="Brault A" first="Antoine" last="Brault">Antoine Brault</name></author><author><name sortKey="Saleem, Ammar" sort="Saleem, Ammar" uniqKey="Saleem A" first="Ammar" last="Saleem">Ammar Saleem</name></author><author><name sortKey="Arnason, John T" sort="Arnason, John T" uniqKey="Arnason J" first="John T" last="Arnason">John T. Arnason</name></author><author><name sortKey="Musallam, Lina" sort="Musallam, Lina" uniqKey="Musallam L" first="Lina" last="Musallam">Lina Musallam</name></author><author><name sortKey="Haddad, Pierre S" sort="Haddad, Pierre S" uniqKey="Haddad P" first="Pierre S" last="Haddad">Pierre S. Haddad</name></author></analytic><series><title level="j">Evidence-based complementary and alternative medicine : eCAM</title><idno type="ISSN">1741-427X</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Populus balsamifera L. (BP) is a medicinal plant stemming from the traditional pharmacopoeia of the Cree of Eeyou Istchee (CEI-Northern Quebec). In vitro screening studies revealed that it strongly inhibited adipogenesis in 3T3-L1 adipocytes, suggesting potential antiobesity activity. Salicortin was identified, through bioassay-guided fractionation, as the active component responsible for BP's activity. The present study aimed to assess the potential of BP and salicortin at reducing obesity and features of the metabolic syndrome, in diet-induced obese C57Bl/6 mice. Mice were subjected to high fat diet (HFD) for sixteen weeks, with BP (125 or 250 mg/kg) or salicortin (12.5 mg/kg) introduced in the HFD for the last eight of the sixteen weeks. BP and salicortin effectively reduced whole body and retroperitoneal fat pad weights, as well as hepatic triglyceride accumulation. Glycemia, insulinemia, leptin, and adiponectin levels were also improved. This was accompanied by a small yet significant reduction in food intake in animals treated with BP. BP and salicortin (slightly) also modulated key components in signaling pathways involved with glucose regulation and lipid oxidation in the liver, muscle, and adipose tissue. These results confirm the validity of the CEI pharmacopoeia as alternative and complementary antiobesity and antidiabetic therapies.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">23781256</PMID><DateCompleted><Year>2013</Year><Month>10</Month><Day>18</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1741-427X</ISSN><JournalIssue CitedMedium="Print"><Volume>2013</Volume><PubDate><Year>2013</Year></PubDate></JournalIssue><Title>Evidence-based complementary and alternative medicine : eCAM</Title><ISOAbbreviation>Evid Based Complement Alternat Med</ISOAbbreviation></Journal><ArticleTitle>Populus balsamifera Extract and Its Active Component Salicortin Reduce Obesity and Attenuate Insulin Resistance in a Diet-Induced Obese Mouse Model.</ArticleTitle><Pagination><MedlinePgn>172537</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2013/172537</ELocationID><Abstract><AbstractText>Populus balsamifera L. (BP) is a medicinal plant stemming from the traditional pharmacopoeia of the Cree of Eeyou Istchee (CEI-Northern Quebec). In vitro screening studies revealed that it strongly inhibited adipogenesis in 3T3-L1 adipocytes, suggesting potential antiobesity activity. Salicortin was identified, through bioassay-guided fractionation, as the active component responsible for BP's activity. The present study aimed to assess the potential of BP and salicortin at reducing obesity and features of the metabolic syndrome, in diet-induced obese C57Bl/6 mice. Mice were subjected to high fat diet (HFD) for sixteen weeks, with BP (125 or 250 mg/kg) or salicortin (12.5 mg/kg) introduced in the HFD for the last eight of the sixteen weeks. BP and salicortin effectively reduced whole body and retroperitoneal fat pad weights, as well as hepatic triglyceride accumulation. Glycemia, insulinemia, leptin, and adiponectin levels were also improved. This was accompanied by a small yet significant reduction in food intake in animals treated with BP. BP and salicortin (slightly) also modulated key components in signaling pathways involved with glucose regulation and lipid oxidation in the liver, muscle, and adipose tissue. These results confirm the validity of the CEI pharmacopoeia as alternative and complementary antiobesity and antidiabetic therapies.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Harbilas</LastName><ForeName>Despina</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Canadian Institutes of Health Research (CIHR) Team in Aboriginal Antidiabetic Medicines, Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, QC, Canada H3C 3J7 ; Natural Health Products and Metabolic Diseases Laboratory, Department of Pharmacology, Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, QC, Canada H3C 3J7 ; Institute of Nutrition and Functional Foods, Université Laval, Quebec City, QC, Canada G1V 0A6 ; Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada H1W 4A4.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vallerand</LastName><ForeName>Diane</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Brault</LastName><ForeName>Antoine</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Saleem</LastName><ForeName>Ammar</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Arnason</LastName><ForeName>John T</ForeName><Initials>JT</Initials></Author><Author ValidYN="Y"><LastName>Musallam</LastName><ForeName>Lina</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Haddad</LastName><ForeName>Pierre S</ForeName><Initials>PS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>05</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Evid Based Complement Alternat Med</MedlineTA><NlmUniqueID>101215021</NlmUniqueID><ISSNLinking>1741-427X</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>02</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>04</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>6</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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